国产聚四氟乙烯膜对牙周膜细胞生长及实验性牙周组织再生的影响

THE INFLUENCE OF POLYTETRAFLUOROETHYLENE MEMBRANE ON CELL GROWTH OF PERIODONTAL MEMBRANE AND EXPERIMENTAL REGENERATION OF PERIODONTAL TISSUE

通过对国产膨体聚四氟乙烯 (e PTFE)膜对牙周膜细胞 (PDLC)生长以及对牙周组织再生 (GTR)与牙周骨质再生的影响 ,探讨该膜的临床应用前景。结果发现PDLC可以在e PTFE膜上良好的生长 ,膜对细胞无毒性及抑制作用 ,扫描电镜观察到细胞与膜附着紧密。在动物实验中 ,组织学观察发现e PTFE膜特殊的孔隙结构对牙槽骨缺损的愈合有保护和促进的作用 ,如果膜的冠向边缘封闭得好 ,对结合上皮的根向迁移有一定的抑制作用 ,有利于新生牙槽骨及牙骨质的修复再生和新附着的建立 ,不失为一种前景看好的替代产品。

The effects of polytetrafluoroethylene (e PTFE) membrane on periodontal ligament cell (PDLC) growth and periodontal tissues and new cement regeneration were studied, and the prospects of clinical application of e PTFE membrane were discussed. The results showed that PDLC grew well on the e PTFE membrane and no toxicity or inhibition was found. Close adhesion of the cells to the membrane was observed by scanning electron microscope. Histological studies suggested that the peculiar porous structure of e PTFE membrane protects and promotes healing of alveolar bone defect when the membrane edge was sealed perfectly on the crown side,exhibiting inhibition of growth of epithelium towards tooth root. The membrane was beneficial to regeneration of new alveolar bone and cement and establishment of new adhesion,and was regarded as a good substitute of old materials.