肺硬化性血管瘤的诊断与治疗

THE DIAGNOSIS AND TREATMENT OF PULMONARY SCLEROSING HEMANGIOMA

回顾性分析了解放军总医院近 2 0年收治的肺硬化性血管瘤 40例。结果 ,2 4例 (6 0 % )患者为中老年女性 ,16例 (40 % )患者有症状 ,37例 (92 5 % )胸片表现为肺内边缘清晰的结节或肿块影 ,全部行手术治疗 ,无手术并发症和手术死亡。免疫组化研究显示 ,肿瘤细胞神经内分泌标志物阳性 ,电镜检查可见胞浆内数量不等的神经内分泌颗粒。术后随诊无转移复发。提示肺硬化性血管瘤是一种来自肺神经内分泌细胞的良性肿瘤 ,手术治疗效果良好。

Forty patients with pulmonary sclerosing hemangioma treated from 1971 to 1999 in General itospital of PLA were analyzed retrospectively for clinical and pathological features,and image characteristics. The results showed that 60%(24 of 40) of patients were middle aged or elderly women,and 40% (16 of 40) of patients had symptoms.On chest radiography,the tumor presented as a round or nearly round nodule or mass with sharp and smooth margin in 37 cases(92 5%).All patients received operation without complication or mortality.Immunohistochemical findings indicated that the tumor cells were positive for neuroendocrine markers,and neurosecretory granules were found in tumor cells by electron microscopy.There was no recurrence or metastasis at the follow up. It suggested that pulmonary sclerosing hemangioma is a benign neuroendocrine tumor that has a good prognosis if it is treated by operation.