摘要
目的 观察不稳定型心绞痛患者血浆神经肽Y(NPY)含量的变化 ,并与稳定型心绞痛患者和正常人进行对照 ,认识其变化的意义。方法 选择不稳定型心绞痛患者 15例 ,稳定型心绞痛患者 2 0例 ,正常对照者 2 0人 ,采用放免法测定血浆NPY水平。结果 不稳定型心绞痛患者发作期血浆NPY水平为 2 0 2 .12± 35 .34 pg/ml ,明显高于稳定型心绞痛患者及正常对照者的 16 4.45± 2 4.2 7pg/ml和 15 6 .35± 2 1.84pg/ml(均P <0 .0 5 )。且经 2周治疗后 ,不稳定型心绞痛患者血浆NPY含量显著下降至 15 9.6 6± 18.75 pg/ml ,治疗前后差异明显 (P <0 .0 5 )。 结论 血浆NPY水平在不稳定型心绞痛患者发作期显著升高 ,NPY参与了心绞痛的病理生理过程。
Objective To observe changes of plasm neuropeptide Y(NPY) in patients with unstable angina pectoris(UAP), select patients with stable angina pectoris(SAP) and normal subjects as the controls, and recognize their significance. Methods Immunoradiometric assay was used to measure the plasm NPY levels in 15 UAP patients,20 SAP patients and 20 normal subjects.Results It was found that the plasm NPY levels in patients with UAP,SAP and normal subjects were 202.12± 35.34 ,164.45±24.27 and 156.35±21.84 pg/ml. The NPY levels in UAP patients were significantly higher than that in the others, but down to 159.66±18.75 pg/ml after treatment for 2 weeks. There was a significant difference between pretreatment and post-treatment( P <0.05).Conclusion The plasm NPY levels of UAP patients increases significantly during fit. NPY takes part in the process of AP.
出处
《苏州医学院学报》
2001年第2期159-160,共2页
Acta Academiae Medicinae Suzhou
