胃癌组织中MMP-9的表达及与细胞增殖活性的关系

Expression of MMP-9 and relation between MMP-9 and proliferative activity in gastric carcinoma

目的 :研究胃癌组织中基质金属蛋白酶 - 9( MMP- 9)的表达特点 ,探讨其与肿瘤细胞增殖活性之间的关系。方法 :收集 74例胃癌标本 ,采用免疫组织化学 S- P染色技术 ,计算每例切片中癌细胞MMP- 9的阳性率及增殖细胞核抗原阳性指数 ( PLI) ,并结合临床病理参数进行分析。结果 :MMP- 9的表达与癌组织的浸润深度、分化程度、淋巴结转移密切相关 ( P<0 .0 5) ,随着 MMP- 9含量的增加 ,PLI不断增高 ,且具有统计学意义 ( P<0 .0 1)。结论 :具有高增殖活性的肿瘤细胞同时具有较强的分泌MMP- 9的能力 ,MMP-

Objective:To investigate the expression of matrix metalloproteinase 9 (MMP 9) in gastric cancer and to discuss the relation between MMP 9 and the proliferative activity of tumor cells.Methods:In 74 cases of gastric cancer,immunohistochemistry (S P method) was used to calculate the positive rate of MMP 9 and proliferative cell nuclear antigen labeling index (PLI).The clinical pathological parameters were analyzed at the same time.Results:In gastric cancer,the expression of MMP 9 was closely related to the depth of invasion,differentiation and metastasis of lymph nodes ( P <0 05).The stronger expression of MMP 9,the higher level of PLI ( P <0 01).Conclusion:The carcinoma cells with high proliferative activity have the strong tendency to secrete MMP 9 and MMP 9 plays an important role during the invasion and metastasis of gastric carcinoma. [