异环磷酰胺联合方案治疗复发或耐药性妇科恶性肿瘤疗效分析

Clinical Analysis of Recurrent or Drug-resistant Malignant Gynecologic TumorsTreated with Ifosfamide Combined Chemotherapy

[目的]评价异环磷酰胺(IFO)方案对复发或耐药性妇科恶性肿瘤的疗效和毒性反应。[方法]以IFO为主联合化疗 ,治疗35例以往多药多疗程联合化疗失败或复发的卵巢、宫颈、宫内膜及阴道恶性肿瘤。[结果]完全缓解9例 ,部分缓解11例 ,总有效率为57 1 %(20/35)。主要毒性反应为骨髓抑制、消化道反应和脱发。[结论]IFO联合方案对多药耐药性妇科恶性肿瘤均显示出较好疗效 ,是目前治疗耐药或复发性妇科恶性肿瘤的有效方案。

To evaluate the effect and toxicity of ifosfamide (IFO) combined chemotherapy in recurrent or drug resistant malignant gynecologic cancer.Thirty five patients with recurrent or drug resistant ovarian,cervical and endometrial cancers and vaginal malignant tumor were treated with IFO combined chemotherapy.Among 35 patients,complete response were observed in 9(25 7%) and partial response in 11(31 4%) with an overall response rate of 57 1% .The main toxic effects were myelosuppression,gastrointestinal reaction and alopecia.The cardiac,liver,renal and bladdery toxicities were mild.[Conclusion]IFO combined chemotherapy reveals good effect in treating patients with recurrent or drug resistant gynecologic cancer.It should be considered as an effective agent for gynecologic malignancies.