膀胱癌增殖细胞核抗原与麦胚凝集素受体的相关关系

Expressions of Proliferating Cell Nuclear Antigen and Wheat Germ Agglutinin Receptor in Human Bladder Carcinoma

[目的]探讨增殖细胞核抗原(proliferatingcellnuclearantigen,PCNA)和麦胚凝集素(wheatgermagglutinin,WGA)在膀胱移行细胞癌(TCC)中表达的相关关系。[方法]采用免疫组织化学ABC法对63例TCC标本进行PCNA和WGA受体检测。[结果]PCNA与WGA的强阳性表达随着肿瘤的病理分级升高而增高 ;浸润性肿瘤中的WGA受体的强阳性表达显著高于浅表性肿瘤(P<0 05) ;PC NA与WGA受体表达一致性良好 ,呈显著性相关(P<0 005)。[结论]我们认为PCNA和WGA受体均可作为TCC的肿瘤标记物 。

To probe the relation of proliferating cell nuclear antigen (PCNA) and wheat germ agglutinin (WGA) receptors expressed in human bladder transitional cell carcinoma (TCC).PCNA and WGA receptors were detected by immunohistochemical method (ABC method) in 63 specimens of TCC.We found that the distributions of PCNA and WGA receptors were increased with increase of histopathological grade in TCC (P<0 01).There was a higher expression in invasive tumors than that in superficial tumors (P<0 005),and there was a positive relation between PCNA and WGA receptors also.[Conclusion]It is shown that PCNA and WGA can be used as tumor markers for bladder cancer.