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临床因素作为乳腺癌预后指标意义的研究 被引量:2

A Study of Clinical Factors Influencing Prognosis of Breast Cancer
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摘要 [目的]探讨临床指标联合预测值(PI值)与乳腺癌预后关系。[方法]回顾分析1992年1月至1997年12月 ,可切除性乳腺癌患者659例。多因素分析 :COX比例风险模型。[结果]淋巴结转移、肿块位置、大小、服用三苯氧胺是影响生存的重要因素。四指标联合预测值(PI值)低危组1年,3年 ,5年的生存率为99% ,97 % ,97 % ,中危组为98 % ,94 % ,86 % ,高危组为94 % ,79 % ,67 % ,三组间P<0 0001;低危组1年,3年 ,5年无复发生存率为98 % ,91 % ,88 % ,中危组为96 % ,83 % ,75 % ,高危组为87 % ,62 % ,51 % ,三组间P<0 0001,PI值与预后负相关。[结论]淋巴结转移、肿块位置、大小、服用三苯氧胺是乳腺癌术后独立的预后指标。PI值是临床评价病人预后 ,发现高危人群很有价值的指标。 To investigate the relationship between the PI(prognostic index) and prognosis of breast cancer patients.A total of 659 patients with operable breast cancer from Jan.1992 to Dec.1997 was analyzed.Multivariate analysis was done by COX proportional hazard model.Lymph node,tumor site,tumor size and postoperative adjuvant tamoxifen therapy were important factors influencing prognosis.According to PI value,1 ,3 , and 5 year overall survival (OS) were 99%,97% and 97% for low risk group;98%,94%,86% for moderate risk group;and 94%,79%,67% for high risk group respectively.Recurrence-free survival (RFS) of 1 ,3 and 5 year was 98%,91%,88% for low risk group;96%,83%,75% for moderate risk group;and 87%,62%,57% for high risk group respectively.[Conclusion]Lymph node,tumor site,tumor size and postoperative tamoxifen therapy was independent predictors of prognosis.PI value may be a useful clinical index for evaluating the prognosis of patients and identifying high risk population.
出处 《肿瘤学杂志》 CAS 2001年第1期43-44,共2页 Journal of Chinese Oncology
关键词 预测值 COX模型 预后 乳腺癌 breast neoplasms prognostic index COX model prognosis
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同被引文献16

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