超声引导经皮注射无水乙醇于瘤内治疗肝癌

ULTRASOUND-GUIDED PERCUTANEOUS ETHANOL INJECTION FOR TREATMEAT OF LIVER CANCER

目的 开发一种简便有效、经济安全的肝癌治疗方法。方法 :对 2 5例肝癌患者共 30个结节在超声引导下细针穿刺经皮瘤内注射无水乙醇 ,直接杀灭肿瘤。肿瘤直径 0 .8～ 4cm,每个瘤内注射 1～ 6次 ,注射剂量 6～ 60 ml。结果 :治疗后 5个瘤灶消失 ,1 5个缩小 ,1 0个未增大。直径缩小或不变的肿瘤 ,CT增强扫描动脉期无强化 ,原血清血甲胎蛋白 (AFP)值升高者显著下降 ,经组织学检查的病灶证实完全坏死。注射过的瘤灶无局部复发。结论 :这是一种安全、有效的治疗方法 ,尤其适合于小肝癌和肝转移癌的治疗。

Objective:To devise a new local therapeutic method for liver cancer with characteristics of safety,reliable efficacy,convenience,and low cost.Methods:Percutaneous ethanol injection therapy(PEIT) was performed on 25 patients for total of 30 tumor nodules,by injecting ethanol into the tumor under ultrasound guidance to ablate lesions.The lesions ranged from 0 8 cm to 4 0 cm in diameter.Each lesion underwent 1 6 times of injection,and the total therapeutic volume of ethanol per lesion varied from 6 ml to 60 ml.Results:After treatment,5 lesions disappeared,15 shrinked,and 12 had no change in size.All lesions presented no increase in CT scanning.Serum a feto protein(AFP) cantent decreased remarkedly in all patients whose pretreatment level was high.Underwent histological examination of some lesions presented complete necrosis.No local recurrence was found.Conclusion:It was an effective and safe therapy for liver cancer,especially small liver cancer and liver metastasis.