米非司酮治疗子宫肌瘤166例疗效分析

Effect of Mifepriston for Uterine Leiomyoma:166 Cases Reports

[目的]探讨米非司酮治疗子宫肌瘤的疗效。[方法]子宫肌瘤166例行口服米非司酮治疗 ,12 5mg每日一次睡前口服 ,连服3个月。[结果]患者在治疗期间均出现闭经、症状缓解、子宫体积平均缩小52 68 %(P<0 01)、肌瘤体积平均缩小49 86 %(P<0 05) ,疗效评价CR25例(15 06%)、PR134例(80 72 %) ,有效率为(CR +PR)95 78 %。血红蛋白恢复正常(100 %) ,性激素各项均有下降 ,其中孕酮、催乳素下降明显(P>0 05)。[结论]米非司酮治疗子宫肌瘤有一定疗效 ,副作用小 ,适用于肌瘤直径小于6cm或者子宫小于妊娠70天大小的病例 。

To investigate effects of mifepriston for uterus leiomyoma. One hundred and sixty_six cases with uterus leiomyoma were treated with mifepriston,12.5mg once a day before sleeping for 3 months .The average uterine volum diminished in 52.68%(P<0.01) and average volum of leiomyoma diminished in 49.86% (P<0.05) .Of 166 cases ,25 cases were CR(15.06%);134 cases, PR(80.72%).The response rate (CR+PR) reached 95.78%.The hemoglobin returned to normal in all the case. Sex hormones decreased, especially progestrone and prolactin decreased significantly.[Conclusion] Mifepriston is effective against uterine leiomyoma with less side effect. It’s fit for case of leiomyoma diameter less than 6cm ,or uterine volum less than 70 gestational days. It’s an acceptable conservative therapy.