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CAF-HD-MIX与CAF方案治疗晚期乳腺癌的疗效比较 被引量:3

Therapeutic effects of CAF-HD-MTX and CAF regimens on treatment of advanced breast cancer: A comparative study
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摘要 目的:比较环磷酰胺(CTX)、阿霉素(ADM)、氟尿嘧啶(5FU)及大剂量氨甲喋呤(HD-MTX)组成的CAF-HD-MTX方案与CTX、ADM及5FU组成的CAF方案治疗晚期乳腺癌的疗效.方法:90例晚期乳腺癌随机分成两组,每组均为45例.结果:CAF-HD-MTX组完全缓解率20.0%(9/45),总有效率80.0%(36/45);CAF组完全缓解率13.3%(6/45),总有效率46.7%(21/45).统计学分析,完全缓解率没有显著差异(P>0.05).总有效率有非常显著差异(P<0.01).主要毒副反应,其中CAF-HD-MTX组的肝功损害及口腔炎较CAF组有明显差异(前者P<0.01,后者P<0.05).而骨髓抑制及胃肠道反应两组均无显著差异(P>0.05).结论:CAF-HD-MTX方案治疗晚期乳腺癌有效率高,病人可耐受,可在临床上进一步观察使用. Objective: To evaluate the therapeutic effects of CAF-HD-MTX (CTX+ADM+5FU+HD-MTX) regimen and CAF(CTX +ADM + 5FU )regimen on ad vanced breast can cer Method: Ninty cases of advanced breast cancer were randomly divided into two groups, in which 45 were treaed with CM-HD-MTX regimen and 45 with CAF regimen. Result: In 45 areiving CAF-HDMTX regimen, the complete remission rate was 20.0%(9/45) and the overall response oue as 80.0%(36/45), and in the other 45 remission rat was 13.3%(6/45) and the overall response rae was 46.7%(21/45), with a significant diffmce (P<0.01) in ovcrall response tale betwcen the two groups. Liver function damage and mucositis of CAF-HD-MTX regimen wee more serious than those of CAF regimen (The former P<0.01, The latter P<0.05). Howevef, both myelosuppression and gastrintestinal bo edion had no staistic difference between two regimens (P>0.05). Conclusionf CAf-HD-MTX regimen may be more effective than CAF regmen,with the moderate toxicity It is worth further studying.
出处 《黑龙江医药科学》 2000年第3期26-27,共2页 Heilongjiang Medicine and Pharmacy
关键词 乳腺癌 环磷酰胺 阿霉素 氟尿嘧啶 氨甲喋呤 联合化疗 治疗 breast cancer combination chemotherapy CAF-HD-MTX regimen CAF regimen
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  • 1张斌,蔡玉娥,张齐,英子伟,蒋书玲,徐宏,郑勇学,姜大庆.CMF与FAC化疗方案在可手术的乳腺癌术前应用对比[J]中国肿瘤临床,1993(06).

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