原发性肾病患儿血GSHPX/LPO比值的探讨

Discussion on ratio of blood GSHPX/LPO in children with primary nephrotic syndrome

本文观察了40例2－13岁原发性肾病患儿血GSHPX/LPO比值变化，对照组为50例体检健康儿童．结果表明：肾病组血GSHPX/LPO比值较对照组极显著降低（P<0.01），本病确实存在氧化与抗氧化平衡失调，为肾病的抗氧化治疗提供了又一客观理论基础．

The raio of the blood GSHPX/LPO was measured in 40 patients with idiopathic nephrotic syndrome (INS) aged from 2 to 13 years. The serum LPO was determined by TBA fluorophotometry The whole blood GSHPX was determined by DTNB direct assay. The results showed that the ratio of blood GSHPX/LPO in 40 patients with INS was much lower than that of the controls (P<0.01), Suggesting that this disease had imbalance between oxidation and antioxidation. Also this study provided theoretic basis for antioxidant drugs to treat INS.