单纯疱疹性角膜炎发病机制研究的新进展

The latest advances in understanding the pathogenesis of herpes simplex keratitis

单纯疱疹性角膜炎（ｈｅｒｐｅｓｓｉｍｐｌｅｘｋｅｒａｔｉｔｉｓ，ＨＳＫ）是主要的致盲眼病之一，主要由单纯疱疹病毒Ⅰ型（ＨＳＶ－Ⅰ）感染眼部引起。近１个世纪以来，有关ＨＳＶ－Ⅰ眼部感染的研究吸引着众多的科学家。早在１８７３年，人们就认识到ＨＳＶ－Ⅰ是导致眼部感染的致病因素之一，Ｇｕｎｔｅｒ和Ｌｏｗｅｎｓｔｅｉｎ曾经推测ＨＳＶ－Ⅰ感染很可能与中枢神经系统有关，自从１９７１年首次通过器官培养从潜伏感染的三叉神经节（ｔｒｉｇｅｍｉｎａｌｇａｎｇｌｉｏｎ，ＴＧ）中分离出ＨＳＶ－Ⅰ之后，人们正在运用各种技术对ＨＳＫ的发病机制尤其是ＨＳＶ－Ⅰ在感觉神经和中枢神经系统中的潜伏状态和复发机制进行研究和说明。对有关的研究进行综述，供参考。

? Herpes simplex keratitis(HSK) is one of the major eye diseases which can cause blindness.It is mainly caused by HSV Ⅰ infection.Over the past one century,many scientists have taken part in the study of HSV Ⅰ eye infection with great interest.As early as 1873,we had already realized that HSV Ⅰ was one of the pathogenic factors which could cause eye infection.Gunter and Lowenstein once supposed that the central nervous system may have something to do with HSV Ⅰ infecton.Since the first isolation of HSV Ⅰ from latently infected trigeminal ganglion by organ culture,scientists have developed new techniques to research the pathogenesis of HSK especially about its latentt infection and the recurrence in sensory nervous system.They are particularly interested in its latent infection and the recurrence in sensory nervous system and central nervous system.The author reviews some literature about the latest advances in understanding the pathogenesis of HSK.