氯丙嗪对酵母细胞积累1，6－二磷酸果糖的影响

The Influence of Chlorpromazine on Fructose-1,6-diphosphate Accu-mulation by Yeast Cells .

用氯丙嗪通透啤酒酵母细胞，其最适积累１．６－二磷酸果糖浓度为４．０ｍｇ／ｍｌ（１．１２７×１０－２ｍｏｌ／Ｌ）最佳反应时间为４ｈ，１．６－二磷酸果糖的最大转化率为理论转化率的４９％。用甲苯处理面包干酵母后几乎不积累１．６－二磷酸果糖，然而用氯丙嗪处理面包干酵母，１．６－二磷酸果糖积累显著增加，表明氯丙嗪具有通透细胞壁及抑制醛缩酶双重作用。

hlorpromasine was selected for accumulating Fructose-1,6- diphosphate by yeast cells. The optimumconcentration was about 4.0mg/ml( 1.127×102ml/L),the optimun duration of reaction was4hours,the highest conversion rate from glucose to FDP was 49% of theoritical conversion rate. Afterbeing treated with toluence,the dried baker's yeast failed to accumulate FDP.But after being tceatedwith the addition of chlorpromasine,the FDP accumulation was remarkablv increased.