摘要
对原始出发菌株-S1P1C1.727交替使用亚硝基胍(NTG)及紫外线(UV)进行诱变处理,经过纯化,再用超声波和UV复合处理,纯化得到一株高产菌株-cou2'11,使摇瓶单位提高了七倍,五立升玻璃发酵罐单位达到1000u/ml以上。
high yield streptokinase mutant named strain Cou 2'11 was obtained by
alternate treatment withNTG and UV-radiation and the combining treatment with ultrasonic and
UV-radiation. The potency ofstreptorkinase increased to f100 u/ml.
出处
《药物生物技术》
CAS
CSCD
1995年第4期56-57,共2页
Pharmaceutical Biotechnology