以糖类为基础的药物──兼论以结构为基础的药物设计

Carbohydrate-based Drugs-Moreover Structure-based Drug Design

糖类是自然界广泛存在的一大类生物分子，它们参与了很多重要的生理和病理过程。这些过程的分子基础都是糖类和蛋白质的相互作用。为此分离有关的糖类，测定其结构，并以此为基础，就能设计和开发出一类崭新的药物。本文介绍了近年来开发的几种以糖类为基础设计的新药：抗炎药物，抗粘着药物和抗流感药物。以结构为基础的药物设计，可以打破原有的化合物分类的框子。更有利于新药的研制和开发。

arbohydrates are a large group of biomolecules which are diStributed widely in nature and involved in a great variety of physiological and pathoiogical processes. The molecular basis of these processes are in-teractions between carbohydrates and proteins. besed on separating and structural determining of relat-ed carbohydrates,a series of new kinds of drugs can be designed and developed. In this paper some kinds of carbohydrate-based drugs are recommended,including antiinflamation, antiadhesion and antiin-fluenza drugs.Some methods which have been used to design carbohydrate-based drugs,e,g. the deter-mination of complex of receptors with ligands,the visualixation of complexes and search of more effec-tive ligands by some software on computer,all are suitable to design other kinds of drgus. Structure-based drug design could break the original classification of compounds,and contribute to design and de-velopment of new kinds of drugs.