p185和p16在乳腺癌中的表达及其意义

Clinicopathologic study on p185 and p16 proteins in human breast cancer

目的 探讨癌基因c erbB 2蛋白 p185和抑癌基因蛋白 p16在乳腺癌中表达的生物学意义。 方法 应用免疫组化S P法检测 5 9例乳腺癌组织中p185和 p16蛋白的表达状况。结果 p185和 p16阳性率分别为 47%和 34 %。两者无相关性 (P >0 0 5 )。p16表达与临床病理特征无明显相关。淋巴结转移组的 p185阳性率为 6 4% ,是无淋巴结转移者的两倍 (32 % ) (P <0 0 5 )。结论 p185过表达和 p16失表达在乳腺癌的发生发展中各自发挥独立的作用。

Objective To investigate the biological significance of p185 and p16 in breast cancer. Methods Immunohistochemical S-P method was used to detect the expression of p185 and p16 proteins in 59 breast carcinomas,and their relations to clinicopathologic features were analyzed. Results The positive rates of p185 and p16 were 47% and 34% respectively. No significant association was evident between the two proteins. There was also no significant relation between p16 expression and clinicopathologic features. p185 positive rate was 64% in the group of lymph-node involvement that was higher than that being 32% lymph-node negative one (P<0.05). Conclusion p185 and p16 may play important roles independently in the development of breast cancer through different pathways. p185 detection is of important value in breast cancer.