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幽门螺杆菌感染时的凝血与溶血系统改变

Coagulation and hemolytic system changes in the patients with helicoba cter pylori infection
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摘要 目的 研究幽门螺杆菌(HP)感染时的凝血与溶血系统 主要指标的改变,探讨HP感染与冠心病的关系。方法 选择HP阳性 患者和HP阴 性对照各60例,测定凝血系统主要指标-纤维蛋白原(Fb)和溶血系统指标-组织纤溶酶原激活 物(t-PA)、纤溶酶原激活物抑制剂(PAI);并对HP阳性患者治疗前后的上述指标进行测定。 结果 HP阳性患者组的Fb为(3.34±0.45)g/L高于对照组的(2.96 ±0.52)g/L(P<0.05);t-PA为(0.78±0.12)kIU/L低于对照组的(1.25±0.13)kI U/L(P<0.05);PAI为(9.75±1.24)kAU/L高于对照组的(6.37±1.03)kAU/L(P <0.05);HP阳性组治疗前后上述指标明显改变(均P<0.05)。结论 幽门螺杆菌感染可引起凝血和溶血系统指标改变,增加冠心病的危险。 Objective To observe the changes of coagu lation and hemolytic system in the patients with helicobacter pylori and to find out the relationship between the helicobacter pylori infection and coronary hea rt disease.Methods (1)Sixty HP positive patients and 60 nor mal controls were selected and the main index of coagulation system-fibrinogen(F b)and the index of hemolytic system-t-PA,and PAI were measured.(2)the index desc ribed above were measured again after the treatment for the HP positive patients .Results Fb in HP positive patients was higher(3.34±0.45 )g/L than that in normal controls(2.96±0.52)g/L,P<0.05;t-PA in HP pos itive patients was lower(0.78±0.12)kIU/L than that in normal controls(1.25± 0.13)kIU/L P<0.05;PAI in HP positive patients was higher(9.75±1.24)kA U /L than that in normal controls(6.37±1.03)kAU/L,P<0.05;(2)after the tr eatment,the index above were changed significantly:P<0.05.Concl usion HP infection can cause a significant changes both in coagulatio n and hemolytic system and increase the risk of coronary heart disease.
出处 《中国全科医学》 CAS CSCD 2001年第5期356-357,共2页 Chinese General Practice
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参考文献3

  • 1[1]Mendall MA, Goggin PM, Molineaux N, et al. Relation of Helicobacter pylori infection and coronary heart disease. Br Heart J,1994, 71: 437- 439
  • 2[2]Pard P, Mendall MA, Carrington D, et al. Association of Helicobacter pylori and Chlamydia pneumoniae Infcetions with conorary heart disease and cardiovascular risk factors. BMJ, 1995, 311:711-714
  • 3[3]Torgano G, Cosentini R, Mandelli C, et al. Treatment of Helicobacter pylori and Chlamydia pneumoniae infections decreases fibrinogen plasma level in patients with Ischemicheart disease. Circulation,1999, 30:1555-1559

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