饮酒习惯对丙型肝炎病毒感染者预后影响的研究

A study on influence of drinking habits on prognosis of HCV infect ion

目的 研究饮酒习惯对丙型肝炎病毒(HCV)感染者慢性 化的影响。方法 我们收集142例HCV感染者的资料，以病程＞6 个月，白蛋白/球蛋白＜1.5和/或ALT＞40U者、或临床确诊为慢性丙型肝炎(HC)的患者 ，分入病例组，共76例；凡抗-HCV(+)或/和HCV RNA(+)持续6个月以上不符合慢性丙型肝炎 条件者为对照组，共66例。结果 病例组有饮酒习惯的比例明显高于 对 照组(χ2=8.75，P＜0.003，OR=2.79)，经性别分层分析：男性OR=2.65，女性OR =4.29，OR总=3.30，提示女性HCV感染者饮酒较男性更易发展成慢性肝病；饮酒量＜100 ml/次、OR=3.18，＞300ml/次、OR=5.45，饮酒量与慢性丙型肝炎呈相关关系；持续饮酒 ≤ 5年、OR=1.74，6～15年、OR=3.51，＞15年，OR=5.10，饮酒年限越长，其慢性化的危险 性越大。结论 (1)饮酒可能是导致HCV感染慢性化的重要危险因素；(2 )积极开展健康教育，提高人们的自我保健意识，规劝HCV感染者戒酒可能是预防HCV感染者 慢性化的重要措施之一。

Objective To analyze the influence of dri nking habits on the chronicity of HCV infection.Methods 142 cases of HCV were collected.Among them,76 cases were defined as the case grou p,their disease course over 6 months，albumin/globulin＜1.5and/or ALT＞40unit s，the other 66 cases be defined as the control group.The drinking habits of bo th groups were compared.Results The drinking habits were p ositively associated with chronicity of HC.There were greatly differences betwe en the drinking habits in case group and those in control group.Stratified anal ysis showed that the females of HCV infection would develop chronicity of HCV in fection easer than males in drinking habit.Conclusion Drin king habit may be one of the risk factors of chronicity of HCV infection.It is beneficial for patients to give up drinking habits to prevent from HCV infection .