胆道感染细菌的变迁及细菌对抗生素敏感性分析

Changes of biliary bacteria and analysis of their sensitivity to antibiotics

目的 了解近 10年胆汁中感染细菌群变化及其对抗生素的敏感性。方法 将 1988年6月至 1998年 7月 10 0例胆汁培养阳性的 12 0株需氧菌及其对抗生素敏感性试验结果进行统计分析。结果 12 0株细菌中包含着 34种菌种 ,其中动力细菌占 6 0 % ,无动力细菌占 2 0 .8%。在 2 1例混合感染的病人中 7例感染绿脓杆菌。庆大霉素对常见阴性杆菌的耐药性增加 ,头孢菌素的第 3代抗菌效果较好 ,但也有一定耐药率。喹诺酮类的环丙沙星对胆道感染各菌种有高度敏感性 ,对绿脓杆菌也有71.4%以上的有效率。结论 与 80年代初期比较 ,胆道感染菌种在增加 ,菌群在变迁 。

Objective To investigate changes of biliary bacteria and their sensitivity to antibiotics in recent 10 years. Methods The data of 120 strains of aerobes found in 100 patients with positive bile culture from 1988 to 1998 and their sensitivity to antibiotics were statistically analyzed. Results The 120 strains of aerobes belonged to 34 species. Of these strains, 60% were mobile bacteria and 20.8% immobile ones. Among 21 cases of mixed infection, 7 were infected with pseudomonas aeruginosa. The bacteria were highly resistant to gentamycin and the 3rd generation of cephalosporins. However, they were highly sensitive to ciproloxacin and quinelone. The sensitivity of pseudomonas aeruginosa to these two agents was as high as 71.4%. Conclusions Now the bacterial species in the bile and their resistance to antibiotics are increased as compared with those in early 1980s.