对老年冠心病患者血清肌钙蛋白、肌红蛋白动态观察的意义

Clinical Significance of Examining Serum Cardiac Troponin and Myoglobin in Elderly Patients with Coronary Heart Disease

目的 探讨老年人血清心肌钙蛋白 (cardiac troponin I,CTn I)和肌红蛋白 (m yoglobin,Mb)的含量与增龄的关系。方法 用放射免疫方法 (radioimmunoassay,RIA)测定 12 1例健康老人 ,32例老年冠心病 (coronary cardiopathy,CHD)患者及 6 0例正常人血清CTn I和 Mb含量。结果 健康老年人血清中 CTn I,Mb含量增大与年龄无相关性 (r =0 .342 1,P >0 .0 5 ) ;健康老年人血清中CTn I,Mb含量与正常成人组相比有显著升高 (P <0 .0 5 ) , 老年 CHD血清中 CTn I, Mb含量显著高于健康老年组及正常成人组 (P <0 .0 1)。提示 CTn I,Mb测定可早期发现老年人心肌损伤 ,并对 CHD病情变化及判断预后有重要意义。故老年人定期观察血清 CTn I,Mb含量及对老年 CHD患者进行健康教育 ,以及加强心肌保护治疗措施 ,可降低

Objective To examine the relationship between change in serum concentration of cardiac troponin I (CTnI), myoglobin (Mb) and age. Methods Serum CTn I and Mb were measured by radioimmunoassay in 121 healthy elderly subjects, 60 normal subjects and 32 elderly patients with coronary heart disease (CHD). Results The results showed that CTn I and Mb had no correlation with age in the healthy elderly group (r=0.3421, P<0.05), though they were significantly higher than those of the normal group (P<0.05); CTn I and Mb were significantly high in the CHD group as compared with the other two groups (P<0.01). Conclusion Serum CTn I and Mb may predict myocardial injury early in the ederly and be of important significance in execting the outcome and the development of myocardial injury in the aged patients with CHD.