口腔颌面部肿瘤患者外周血淋巴细胞微核的检测

Detection of Micronucleus in Peripheral Blood Lymphocytes of Patients with Tumors in Oral and Maxillofacial Regions

本文采用微量血培养法测定了43例口腔颌面部肿瘤及癌前病变患者外周血淋巴细胞微核,检出率为100%。口腔颌面部恶性肿瘤、癌前病变及良性肿瘤患者外周血淋巴细胞微核率分别为14.07±3.98‰、12±1.414‰和8.64±2.098‰,与对照组(5.95±1.91‰)比较有非常显著差异(P<0.005)。恶性肿瘤与良性肿瘤患者外周血微核率差异亦有高度显著性(P<0.005)。恶性肿瘤患者微核淋巴细胞的多微核淋巴细胞出现率在7.89%,明显高于良性肿瘤患者的2.48%和正常人的2.4%(P<0.05)。结果提示外周血淋巴细胞微核的检测可作为口腔颌面部癌肿辅助诊断和估计预后的指标;口腔颌面部肿瘤的发生与染色体畸变可能有密切的关系。

Micronucleus rate(MNR)in peripheral blood lymphocyte(PBL)of 43 patients withtumor and precancerous lesion in oral and maxillofacial regions were detected by meansof the method of peripheral blood lymphocyte culture.The detectable rate was l00%.MNRinPBL in malignant tumor,precancerous lesion and benign tumor were 14.07±3.98％12±1.414%and 8.64±2.098% respectively.Compared with control,it was highly significantdifferent(P<0.005).The difference of MNR in PBL between the groueps of malignanttumor and benign tumor was also highly significant different(P<0.005).The multi-micro-nucleus rate in PBL of patients with malignant tumor was 7.89%.It was clearly higher thanthose of benign tumor(2.48%)and control group(2.4%)(P<0.05%).The results suggestedthat MNR may be used as supplementary index in diagnosing malignant tumors and ev-aluating prognosis.The histogenesis of tumors in oral and maxillofacial regions may beclosely relative with chromosomal aberration.