摘要
Human antisense GST-πRNA was transferred into adriamycine-treatedadenocarcinoma cell of lung. The over-expression of GST-πgene wasinhibited and the total GST activity towards CDNB, the test substrate, wasdecreased. Transfected cells showed elevated sensitivity to adriamycine ascompared with un-transfected cells. The results suggest that GST-π plays arole in drug resistance of human adenocarcinoma of lung, and inhibition ofGST eazymes might partially restore the sensitivity of cancer tochemotherapy.
