摘要
本文报道了11β—取代17α—丙炔基甾体化合物的合成,并详述了丙炔气体制备的一种简便方法。17α—丙炔基的引入是 RU—486具有抗孕酮和抗糖皮质激素活性的重要基团之一。
The synthesis of one 17 α-(prop-1-ynyl)-11β substituted steroid compound is reported and a simple proc- ess of preparing propyne gass is stated in detail. The introduce of 17α-(prop-1-ynyl) group is one of important groups which leads RU-466 having autiprogesterone and antiglucocorticoid activity.
出处
《华西药学杂志》
CAS
CSCD
北大核心
1991年第4期217-220,共4页
West China Journal of Pharmaceutical Sciences