成都市340名绝经后妇女骨质疏松发病情况调查及影响因素探讨

Study on Morbidity and Relative Factors of Postmenopausal Osteoporosis in 340 Women in Chengdu

作者测定了成都市340名绝经后妇女桡骨骨矿物含量及血碱性磷酸酶、血钙、血磷、尿钙、尿磷、尿羟脯氨酸和尿肌酐,并对有关因素进行调查。结果显示:绝经后骨质疏松患病率为25％,患病率随年龄及绝经年限增长而增加。用多元逐步回归分析,从16种有关因素中筛选出血钙、尿钙、血碱性磷酸酶、尿羟脯氨酸、产次、年龄与骨矿物含量相关。用这6种指标进行骨质疏松Fisher判别分析,诊断符合率达75.2％。本文还对这些因素的临床意义进行了讨论。

In this cross-sectional study,the radius bone mineral content (BMC)of340 postmenopausal women (mean age:53;mean years since menopause. 5.56) wereasscssed by single photon absorptiometry(SPA) for determining prevalence ratsof postmenopausas osteoporosis in Cheng-du, and some factors relative to BMCwere investigated. Eighty-five of 340 post-menopausal women were diagnosed osteo-porosis by SPA. The prevalcnce rate,which increases with year since menopauseand age, is 25%. There is significantincrease in prevalence after the age of 60years or 5 years since menopause. Sixteenfactors were analysed by stepwiso regres-sion. The variables selected were serumcaicium(SCa), serum alkaline phosphatase(SAkP), urine calcium (UCa), urinehydroxypoline(UH), age, and Para.Fisherdiscriminant analysis was used for diag-nosis with these variables, the accuracyof diagnosis being 75.2%. Our study show-ed that postmenopausal osteoporosis isa common disease in Chengdu. High SCa,UH, age and low SAkP level may be riskfactors of osteoporosis.