子宫内膜癌的雌激素、孕激素受体含量及其与临床和病理的关系

Relation between the Levels of Estrogen Receptor and Progesterone Receptor and Clinicopathological Status in Human Endometrial Carcinomas

作者采用Lee荧光组织学法测定29例子宫内膜癌及其中9例癌旁内膜的雌激素受体(ER)和孕激素受体(PR)含量。结果发现:术前未经放、化疗的子宫内膜癌都含有ER,PR;腺鳞癌中腺癌成分的ER和PR含量高于鳞癌成分。雌二醇(E_2)和孕酮(P)阻断试验证实ER和PR具有特异性。癌旁内膜的ER和PR含量高于子宫内膜癌。ER和PR阳性水平在早期癌、子宫颈管无累及和高分化癌内较高,与肌层浸润程度及月经状况无关。在19例追踪半年至1年半的病例中,显示ER、PR阳性水平较高的病人预后较好,内分泌治疗也初见效果,但尚需要积累更多病例观察分析。

Estrogen receptor (ER) andprogesterone receptor (PR) assays wereperformed by direct fluorescent histochemi-cal methods in 29 endometrial carcinomasand 9 endometria of para-carcinomas.ER+and PR+were found in the pat?entswho had not received chemotherapy and/or radiotherapies. In 4 adenosquamouscarcinomas. the contents of ER and PR ofadenocarcinoma components were higherthan those of squamous carcinoma compo-nents. Blocking tests proved the specificityof ER and PR for estradiol and progesteronerespectively. The levels of ER and PR inendometria of para-carcinomas were higherthan those in carcinomas There werehigher levels of ER and PR in eaxly clinicalstage than in advanced stage, in cases freefrom cervical involvement than in casescervical involvement, and in well differ-entiated carcinomas than in poorly differ-entiated carcinomas. ER and PR contentsdid not correlate with the depth of myo-metrial invasion or menopausal status. Inthe patieat group followed up for half ayear or more, 4 patients with hih-levelER and PR had a good response to 17α-progesterone caprate. The patients withER+and PR+had a longer survival periodthan those with ER-and PR-.Ourresults indicated that the assay of ER andPR might be valuable for predicting theresponse to endocrine therapy and prog-nosis for patients with endometrial carci-noma.