大鼠小肠原位灌流研究铝、氟混合物的吸收过程

Aluminum and Fluorine Absorption in a Perfusion System of Rat Small Intestine in Vivo

将两种不同比例的铅与氟分别溶解于pH7.0的Tris缓冲液中,原位灌流大鼠小肠40分钟。灌流期检测门静脉血中铝和氟含量。结果显示,高剂量铝比例组(4660μg/ml Al+200μg/ml F)和低剂量铝比例组(860μg/ml Al+200μg/ml F)氟吸收不明显。低剂量铝比例组铝吸收亦不明显,但高剂量铝比例组的铝吸收显著,表明铝拮抗氟毒性的机理主要是铝抑制了肠道对氟的吸收。

Mixtures of aluminum anfluorine in two different ratios in tris-hydroxy-methyl-aminomethane bufferedmedia of pH 7.0 were erfused respectivelythrough the small intestine of the in vivorat over a period of 40 min. The contentsof aluminum and fluorine in ortelvein blood obtained from different perfu-sion periods were detected and determinedsimultaneosly. The results showed thatfluorine bsorption was not significant inthe mixtures. An obviously large amountof aluminum was absorbed in the mix-ture with a higher proportion f alumin-um (466μg/ml Al+200μg/ml F/L), whilein the mixture with a lower dose of alu-minum (860 μg/ml Al+200μg F/L), asmall quantity of luminum was absorbed.It is evident that the mechanism by whichaluminum inhibits fluorine toxicity is thataluminum decreases the ntestinal fluorineabsorption by the formation of aluminumfluoride complex.