摘要
作者采用离子色谱法检测药用炭、三硅酸镁及维那利酮、苄吲唑乙酸中微量氯化物和硫酸盐杂质,并对离子色谱条件进行了研究,建立了检测方法。与中国药典1985年版及1990年版附录初稿所载方法比较,两法所得结果基本一致,但离子色谱法具有选择性好、灵敏度高(可测量ppm~ppb)、可同时检测药物中微量氯化物和硫酸盐,以及操作简便、快速等优点。
Chloride and sulfate inmagnesium trisilicate, activated charcoal,vesnarinone and bendazac were determinedby the IC conductimetric detection. Anal-ysis were performed by using a separatingcolumn(100×6mm i.d.) packed with anionexchanger and with a stripper column(100×6mm i. d.) 1.4mmol/L Na2CO_3 and 1.4,mmol/L Na_2CO_3--0.75mmol/L NaHCO_3 wereused as eluents respectively. The peakheight was linear with concentration from10^(-6). to 10^(-3) mol/L for Cl^- and from 10^(-5) to,10^(-3) ol/L for SO_4^(2-) Results showed nosignificant difference as compared withthose determined by the CHP (1985) andCHP (1990) ppendices methods. The ICmethod is specific, sensitive, simple andrapid.
出处
《华西医科大学学报》
CSCD
1991年第2期204-207,共4页
Journal of West China University of Medical Sciences
关键词
色谱法
氯化物
硫酸盐
药物检测
Ion chromatography
Chloride
Sulfate
Determination of drugs