摘要
目的观察Raloxifene(EVISTA)和利维爱(Livial)用于治疗去卵巢大鼠骨质疏松时对血脂的影响。方法32只4月龄雌性SD大鼠随机分为4组 :假手术组、模型组、Raloxifene组及利维爱组 ,每组8只 ,用药60天 ,采血分离血清 ,测定血清总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL_C)、低密度脂蛋白(LDL_C) ,对各组血脂测定值进行比较。结果大鼠去卵巢75天后 ,模型组血脂已有变化 ,表现为TC增高 ,HDL_C降低 ,TC、LDL_C差异无显著性 ;两药物组与模型组比较血脂改善 ,但调脂结果各不相同 :利维爱与Raloxifene均有降低TG、升高HDL_C的作用 ,前者降TC强于后者 ,对LDL_C无明显影响 ;后者升HDL_C强于前者 ,同时还有降低LDL_C作用 ;二者对TG均无明显作用 ;结论大鼠去卵巢后将发生血脂紊乱 ,Raloxifene。
Objective To study the effect of Raloxifene and Livial on the serum lipid of ovariectomized rats. Methods 32 4_month_old SD female rats were randomly divided into 4 groups, namely sham operation group, bilateral ovariectomy group(sample group), ovariectomy plus supplementary Raloxifene group(Raloxifene group), and ovariectomy plus supplementary Livial group(Livial group). Each group induded 8 rats. Experiment period was 60 days. Serum were collected to measure Cholesterol(TC)?triglyceride(TG)?high_density lipoprotein_cholesterol(HDL_C), low_density lipoprotein_cholesterol(LDL_C). Results There were significant differences between groups in serum lipid. In the sample group, TC was higher, HDL_C was lower than that in the sham operation group. In the Raloxifene group and the Livial group TC was lower than that in the sample group and in the sham operation group. In the Raloxifene group HDL_C was higher than that in the sample group and in the Livial group, HDL_C and LDL_C were lower than that in the sham operation group. There were no significant differences between groups in TG. Conclusion The ovariectomized rats had lipid metabolism disorder. Raloxifene and Livial played a role in the lipid metabolism.
