成都地区汉族人群α2HS-糖蛋白的遗传多态性

Genetic Polymorphism of α2HS-Glycoprotein in the Han Population in Chengdu

作者应用等电聚焦免疫固定技术,调查了成都地区286名无血缘关系汉族青年男女的血清α2HS-糖蛋白(AHSG)表型频率。结果AHSG1型占47.20％。AHSG2型占8.04％。AHSG2-1型占44.76％。由此求得a2HS-糖蛋白基因频率AHSG·1为0.6958,AHSG·2为0.3042。个人识别机率为0.5704,非父排除率为0.1669。提示AHSG是一个有用的法医血液遗传标记。

The distribution of α_2HS-glycoprotein (AHSG) phenotype frequen-cies in the Han population in Chengduwas studied using polyacrylamide gel iso-electric focusing followed by immunofixa-tion with rabbit anti-human AHSG serum.Two hundred eighty-six serum samplescollected at random from unrelated indivi-duals were phenotyped for AHSG. Thedistribution of AHSG phenotype frequen-cies was found to be AHSG 1=47.20%,AHSG 2=8.04% and AHSG2-1=44.76%.The observed numbers agreed well withthe expected numbers calculated on thebasis of the Hardy-Weinberg equilibrium.The allele frequencies were estimated tobe AHSG.1=0.6958 and AHSG.2=0.3042.The discrimination probability of AHSGis 0.5704 and the exclusion probability ofparentage 0.1669.