幽门螺杆菌空泡毒素及其单克隆抗体的研究进展

Progress of vacuolating totoxin of Helicobacter pylori and its monoclonal antibody

人幽门螺杆菌（H.pylori）是慢性胃炎和消化性溃疡的主要病因，并与胃癌的发生密切相关。幽门螺杆菌的致病机理与其致病性和宿主免疫应答有关，尤以幽门螺杆菌的毒性占主导地位。最新研究表明，约60%的幽门螺杆菌分离株具有分泌空泡毒素（VacA）的能力，并且血清中其相应抗体的出现与消化性溃疡的发生高度平行。综述了VacA的制备和纯化，理化特性，蛋白质结构，编码基因，致病机理及其单克隆抗体等方面的研究进展。

：Helicobacter pylori is the causative agent of chronic superficial gastritis and peptic ulcer disease and possibly gastris cancer. The pathogenesis of H. pylori is related to its pathogenicity and patient's immune response,especially in which the vacuolating totoxin activity of H. pylori has a major role .The latest studies show that the vacuolating totoxin is produced in vitro by approximately 60% of H. pylori.In this report,the development of purification,as well as the development of characterization of physical chemistry,protein structure,encoded gene and pathogenesis of VacA, and its monoclonal antibody against several pathogenic determinants of H. pylori, is introduced.