食管、贲门癌病人手术前后血清胃泌素水平的动态研究

Pre-and Postoperative Sequential Study on the Level of Serum Gastrin of Patients with Esophageal and Cardiac Cancer

本实验用放射免疫法检测了140例正常人,动态测定了46例食管、贲门癌,40例非癌胸疾病人手术前、后血清胃泌素水平。结果表明:食管、贲门癌病人血清胃泌素水平明显升高,其程度与肿瘤病期、原发肿瘤大小、淋巴结转移,以及组织学类型有密切关系。本实验证明:(1)食管、贲门癌病人切除肿瘤后,其血清胃泌素水平逐渐降低,术后14天左右达正常水平;(2)术后14天胃泌素能恢复至正常者,预后良好,反之,则预后不良。由此,作者认为动态测定血清胃泌素可作为食管和贲门癌诊断、判断预后、监测复发转移的一项重要参考指标。

In this experiment, serial changes of the level of serum gastrin were detected by radioimmunoassay in 46 esophageal and cardiac cancers before and after operation. In comparing these tests with those of 40 cases of noncancerous thoracic lesions and 140 normal abults, the results of the experiment showed that the serum gastrin of the patients with esophageal and cardiac cancers was significantly higher than that of The noncanerous thoracic lesions and normal individuals (P<0.01). The gastrin level was related to the stages of cancer, the size of the primary tumor, the presence of lymph node metastasis and the types of histoclassification. This experiment has confirmed.(1) After remeval of the tumor, the gastrin leveI was decreased gradually from the 7th postoperative day on and returned to normal level on the 14th postoperative day. (2) Those patients whose gastrin could return to normal level on the 14th postoperative day would have a good prognosis. On the contrary, if not their Prognosis would be very poor. Therefore, it appeared that pre-and postoperative serial study on the seram level of gastrin from patients with esophageal and cardiac cancers might be an important parameter for diagnosis, and also in the evaluation of prognosis, postoperative recurrence or metastasis of the tumor.