期刊文献+

经气管肺给药的进展 被引量:2

下载PDF
导出
摘要 经气管肺给药包括经气管肺吸入和注入药物两种途径,前者以气溶胶方式吸入,需借助于气溶胶发生装置,后者是将药液直接注入气管肺内。主要有两个不同的目的:其一让药物经气管肺吸收,在身体其他部位发挥作用;其二让药物在气管肺局部直接发挥作用。给药途径及目的不同,用药后的药代动力学也不一样。近年来该领域日益受重视并不断取得进展。本文就经气管肺给药的生理学基础、药代动力学、临床应用等的进展作一综述。
作者 饶小春
出处 《国外医学(儿科学分册)》 2001年第3期150-152,共3页 Foreign Medical Sciences(Section of Pediatrics)
  • 相关文献

参考文献13

  • 1Johnston C. Endotracheal drug delivery[J]. Pediatr Emerg Care,1992,8(2):94- 97.
  • 2Schreier H, McNicol KJ, Bennett DB, et al. Pharmacokinetics of detirelix following intratracheal instillation and aerosol inhalation in the unanesthetized awake sheep[J]. Pharm Res, 1994, 11 (7):1056- 1059.
  • 3Rathegber J, Zielmann S, Panzer C, et al. Prevention of pneumonia by endotracheal micronebulization of tobramycin[J]. Anasthesiol Intensivmed Notfallmed Schmerzther, 1993,28(1):23- 29.
  • 4Paret G, Vaknin Z, Ezra D, et al. Epinephrine pharmacokinetics and pharmacodynamics following endotracheal administration in dogs:the role of volume of diluent[J]. Resuscitation, 1997,35(1):77-82.
  • 5Kerz T, Dick W. Routes for drug administration during cardiopulmonary resuscitation[J]. Anaesthesist, 1996,45(6):550- 565.
  • 6Bressolle F, Coussaye JE, Ayoub R, et al. Endotracheal and aerosol administration of cefazidime in patients with nosocomial pneumonia:pharmacokinetics and absolute bioavailability[J]. Antimicrob Agents Chemother, 1992,36(7):1404-1411.
  • 7Makhoul IR, Merzbach D, lichtig C, et al. Antibiotic treatment of experimental pseudomnas aeruginosa pneumonia in guinea pigs:comparison of aerosol and systemic administration[J]. J Infect Dis,1993,168(5): 1296 - 1299.
  • 8Leconte P, P otel G, Clementi E, et al. Administration of tobramycin aerosols in patients with nosocomial pneumonia: a preliminary study[J]. Presse Med, 2000,29(2):76- 78.
  • 9Hochhaus G, Mollmann H, Derendorf H, et al. Pharmacokinetic/pharmacodynamic aspects of aerosol therapy using glucocorticoids as a model[J]. J Clin Pharmacol, 1997,37(4):881- 892.
  • 10Mielke L, Entholzner E, Hargasser S, et al. Drug administration via the endobronchial route: possibilities of drug administration in emergency medicine[J]. Fortschr Med, 1994,112(27):377 - 380.

同被引文献2

引证文献2

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部