定量超声与双能骨密度测定在骨质疏松诊断中的应用及评价

Diagnosis of osteoporosis by quantitative ultrasound and dual energy X-ray absorptiometry:application and evaluation

目的 观察定量超声法 (QUS)在骨质疏松诊断中的意义及双能X线骨密度测定法(DEXA)在骨结构评价中的作用。方法 采用Osteospace定量超声跟骨测定仪及HologicQDR 45 0 0A型双能骨密度测定仪 ,对 40例健康体检者同时测定跟骨超声声速 (SOS)、声衰减 (BUA)以及全身、正位腰椎、侧位腰椎、侧位腰椎感兴趣区、股骨近端骨密度 (BMD)。结果 BUA、SOS与大多数部位BMD相关关系显著 (r=0 35～ 0 6 2 ,P <0 0 5或P <0 0 1) ;股骨近端及正位腰椎2 BMD与BUA及SOS的直线回归关系显著 (P <0 0 5 )。结论 QUS是诊断骨质疏松和评价骨强度的良好方法。在DEXA测定部位中 ,股骨近端及正位腰椎2 BMD有较高的评价骨结构特性价值。

Objective To assess the significance of quantitative ultrasound (QUS) in diagnosis of osteoporosis.and the effectiveness of dual energy X-ray absorptiomentry(DEXA) in evaluation of bone structure. Methods Calcaneus BUA and SOS were measured by QUS in 40 healthy adults.Bone mineral density(BMD)of whole body,lumbar,lateral spines and hip were simultaneously determined by DEXA. Results Both calcaneus BUA and SOS were highly correlated with BMD in most of regions( r =0 35～0 62, P <0 05 or 0 01).There was a good linear relationship between BUA and BMD of hip,and also between SOS and BMD of lumbar spines. Conclusion QUS is a better method for diagnosis of osteoporosis and evalution of bone intensity.BMD of hip and lumbar spines have significant value in evaluation of bone structure.