摘要
目的 观察老年性骨质疏松患者转化生长因子 β1 (TGF β1 )、胰岛素样生长因子 - 1(IGF 1) ,表皮生长因子 (EGF)血清水平以及与骨质疏松的相关性。方法 采用双能X线骨密度仪测量了 86例在本院老年病门诊和住院的老年人腰椎正位以及股骨颈、ward三角区、大粗隆部位的骨密度 (BMD) ,受试者均为老年男性 ,平均年龄为 6 9 97± 5 73岁 ,按照WHO推荐的诊断标准 ,参考中国人骨质疏松症建议诊断标准 (第二稿 ) ,将其分为非骨质疏松组 (NOP)、腰椎骨质疏松组 (OP1 )和股骨上段骨质疏松组 (OP2 ) ,测定所有受试者血清TGF β1 ,IGF 1,EGF水平。结果 腰椎骨质疏松组和股骨上段骨质疏松组血清IGF 1浓度值均低于非骨质疏松组 ((P <0 0 1) )。腰椎骨质疏松组血清TGF β1 浓度值与非骨质疏松组无明显差异 ((P >0 0 5 ) ) ,股骨上段骨质疏松组血清TGF β1 浓度值低于非骨质疏松组 (0 0 1<P <0 0 5 ) ,骨质疏松组血清EGF值与非骨质疏松组无差异 (P >0 5 )。腰椎骨密度值与血清IGF 1值呈正相关 (相关系数分别为 :0 2 12、0 32 5、0 2 2 8) ,腰椎骨密度值与血清TGF β1 值呈显著正相关 (相关系数分别为 :0 373、0 32 8、0 341、P <0 0 5 )。股骨颈、Ward三角、大粗隆的骨密度值与IGF 1和TGF β1
Objective To observe the changes of serum transforming growth factor-beta-1(TGF-β 1), insulin-like growth factor-1(IGF-1) and epidermal growth factor(EGF) in the elderly osteoporosis and the correlation between the bone mineral density and TGF-β 1, IGF-1 and EGF. Methods Bone mineral density of the lumbar spine and femur neck was measured with dual energy X-ray densitometer. 86 aged people were divided into three groups:non-osteoporotic group(NOP), lumbar spine osteoporotic group(OP 1), and femur neck osteoporotic group(OP 2). Serum TGF-β 1, IGF-1 and EGF levels were measured by enzyme-linked immunosorbent assay. Results IGF-1 level was much lower in groups OP 1 and OP 2 than those in group NOP( P <0 01). There was no significant difference in serum TGF-β 1 levels between the group OP 1 and group NOP.( P >0 05); in contrast, there was statistically significant difference in TGF-β 1 levels between the groups OP 2 and NOP(0 01< P <0 05). Serum EGF levels had no significant changes in the three groups( P >0 5). There was a positive correlation between BMD and TGF-β 1 and IGF-1. Conclusion TGF-β 1 and IGF-1 are considered as a main factor for maintaining bone mass. Decrease of their production rate in bone may cause osteoporosis. EGF plays an unimportant role in the pathogenesis of osteoporosis.
出处
《中国骨质疏松杂志》
CAS
CSCD
2001年第2期128-130,共3页
Chinese Journal of Osteoporosis