心肌肌钙蛋白I快速检测在急性心肌梗死诊断中的价值

Diagnosis value of rapid cardiac troponin Ⅰ decected for acute myocardial infarction

目的 比较心肌肌钙蛋白I(CTnI)与几种常用的急性心肌梗死 (AMI)诊断标记物的临床应用价值。方法 对36例AMI和70例非心肌梗死患者同时检测血清CTnI、肌酸激酶 (CK)、肌酸激酶同功酶 (CK -MB)、乳酸脱氢酶 (LDH)、天冬氨酸转氨酶 (AST)和α -羟丁酸脱氢酶 (α -HBD)等6项指标 ,并进行2组间比较 ,分别对AMI和非心肌梗死组各指标间的差异作对比分析。结果 CTnI诊断AMI的敏感性 (91.7 % )高于CK(75.0 % )、CK -MB(63.9 % )、AST(66.3 % )、LDH(75.0% )、α -HBD(69.4 % ) ,P<0.05～0.01 ;CTnI诊断AMI的特异性(95.7 %)与CK -MB(92.6 % )相近 (P>0.05) ,高于CK(84.3 % )、AST(81.4 % )、LDH(72.9% )及α -HBD(80.0% ) ,P<0.05～0.01。结论CTnI对AMI的诊断具有较高的敏感性和特异性 ,作为一种心肌损伤的特异标记物 。

Objective To compare the clinical diagnosis value of cardiac troponin Ⅰ (CTnI) and creatine kinase (CK), creatine kinase MB (CK-MB), aspartic transaminase (AST), lactic dehydrogenase (LDH) and α-hydroxybutyric dehydrogenase (α-HBD) in patients with acute mycoardial infarction (AMI). Methods The serum level of CTnI, CK, CK-MB, AST, LDH and α-HBD were simultaneously measured in 36 patients with AMI and 70 patients without myocardial infarction. Results The sensitivity of CTnI for diagnosis of AMI was 91.7% which was significantly higher than that of CK, CK-MB, AST, LDH and α-HBD (75%, 63.9%, 66.7%, 75%, 69.4% respectively, p<0.05～0.01). Moreover, the specificity of CTnI was 95.7%, which was similar to CK-MB (92.6%, p>0.05), while remarkably higher than CK, AST, LDH and α-HBD (84.3%, 81.4%, 72.9%, 80% respectively, p<0.05～0.001). Conclusion CTnI was a useful marker for cardiac damage, which had high sensitivity, specificity and value of clinical used for diagnosis of AMI.