去纤酶治疗急性脑梗死疗效观察

Observation of Short- and Long-Term Effect of Defibrase on Acute Cerebral Infarction (39 Clinical Cases Report)

目的 :评价去纤酶治疗急性脑梗死的近远期疗效。方法 :应用前瞻性随机双盲对照试验 ,以神经功能缺失评分 ,日常生活能力评分 ,血纤维蛋白原等为指标 ,评价该药的近远期疗效。结果 :去纤酶组显著改善神经功能缺失程度 ,提高日常生活能力 ,降低血纤维蛋白原水平 ;1a后随访 ,患者复发率 ,神经功能缺失评分 ,日常生活能力评分均与安慰药组差异显著。结论 :去纤酶可能通过降低纤维蛋白原水平 ,达到保护缺血神经元 ,改善脑供血和神经功能状态 。

Objective: To evaluate the short- and long-term effect of defibrase on acute cerebral infarction. Methods: A prospective, randomized double-blind control method was employed for the study. All the patients were treated with injection of either defibrase or placebo. The scores of neurological function deficits and daily living abilities as well as the level of fibrinogen were tested.Results: The neurological function of the patients treated with defibrase was significantly improved, the scores of daily living abilities increased, and the level of fibrinogen in blood decreased. A follow-up of the subjects at the time point of one year after the treatment revealed that, the recurrence rate of infarction in those treated with defibrase was zero. Meanwhile, the subjects treated with defibrase had significantly decreased scores of neurological function and significantly improved daily living abilities comparing with those treated with the placebo. Conclusion: Defibrase can protect the nurons against ischemia-induced lesion, improve the neuron function by decreasing the fibrinogen level. It has valid therapeutic effect on cerebral infarction.