2型糖尿病心脏自主神经病变与糖尿病肾病的关系

Relationship between Cardiac autonomic nerve dysfunction and diabetic nephropathy in type 2 diabetes mellitus

目的探讨 2型糖尿病心脏自主神经病变与糖尿病肾病的关系。方法使用HolterStar软件监测系统对 6 4例 2型糖尿病肾病患者及 6 0例正常人进行心率变异 (HRV)分析 ,并将HRV测定值与糖尿病肾病患者 2 4小时尿蛋白排泄量进行直线相关分析。结果糖尿病人早期肾病时即有HRV轻度下降 ,临床期肾病时HRV较正常对照组显著下降 (P <0 0 0 1) ,HRV与 2 4小时尿蛋白排泄量呈负相关。结论 2型糖尿病人心脏自主神经病变与肾病并存 ,呈平行关系 ,HRV可用来预测肾病变。

Objective To study the relationship between cardiac autonomic nerve dysfunction (CAND) and diabetic nephropathy (DN) in type 2 diabetes mellitus (DM).Methods The heart rate variations (HRV) in 64 cases with type 2 DN and 60 normal control subjects were performed by Holter Star of computer system, and the linear relative analysis between HRV and the content of 24h urine protein in the DN was evaluated. Results HRV in diabetic patients with early DN was slightly lower, and was significantly lower ( P <0.001) in clinical DN group than that in normal control group. HRV was negatively related to the content of 24h-urine protein. Conclusion CAND is coincided with DN in type 2 DM, CAND is parallel to degree of DN. HRV can be used in predicting DN.