肝硬化患者血浆一氧化氮和内毒素水平及意义

Plasma levels and clinical significance of nitric oxide and endotoxin in patients with cirrhosis

目的观察肝硬化患者血浆一氧化氮 (NO)和内毒素的水平 ,并分析其相关性。方法测定 42例肝硬化患者及 2 7例正常人的血浆一氧化氮及内毒素水平。结果肝硬化组血浆NO及内毒素水平高于正常组 (P <0 0 5 ,0 0 1) ,且随肝功能Child -Pugh分级增加而升高 ;血浆NO水平与内毒素水平呈正相关 (r=0 712 ,P <0 0 1)。结论肝硬化时 ,NO合成增加与内毒素诱导有关 ,同时与肝硬化病情严重程度密切相关。

Objective To observe the levels of plasma NO and endotoxin in cirrhosis patients and analyse their correlation.Methods Plasma levels of NO and endotoxin in 42 patients with cirrhosis and 27 healthy subjects were measured.Results Plasma levels of NO and endotoxin were much higher in patients with cirrhosis than in healthy controls ( P <0 05,0 01). Along with increased of Child-Pugh classify that level of NO were higher in plasma. Plasma NO levels were significantly correlated with endotoxin levels (r=0.712 P <0.01). Conclusion The increase of nitric oxide levels in plasma could be induced by endotoxin, and closely associated with the severity of liver cirrhosis.