微波全身照射对带肿瘤和非带肿瘤大鼠免疫反应的影响

Effects of microwaves (2450MHz) whole-body exposure on the immune responses of tumor-bearing and nontumor-bearing rats.

雌性Fisher 344大鼠照射2450MHz微波(10、20和40mW/cm^2;SAR=3.4、6.8和13.6mW/g)两周,每周5天,每天3小时。带植入乳腺腺癌R-3230 AC动物,照射后脾脏有核细胞密度和血清IgG含量与照射功率密度呈负的剂量—效应关系;外周血非PHA刺激的淋巴细胞转化与功率密度呈正的剂量—效应关系。非带肿瘤动物无上述剂量—效应关系出现。说明带肿瘤动物的免疫系统对微波照射反应的敏感性高于非带肿瘤动物,前者的细胞和体液免疫反应均出现变化,意义有待查明。

Female 344 rats had been exposed to 2450 MHz microwaves(10, 20 and 40mW/cm^2, SAR=3.4, 6.8 and 13.6roW/g) for two weeks, 5 days per week, 3 hours per day. After exposure, it was found in mammary adenocarcinoma R-3230AC tumor-bearing rats that the density of nucleated cells in spleen and IgG in sera presented negative correlation (r=-0.405 and -0.561, P<0.05 and<0.01, respectively) with power density, and nonPHA-stimulated lymphocyte transformation of peripheral blood presented positive correlation (r=0.726, P<0.01) with power density. Nontumor-bearing rats did not present these kinds of correlation. These results indicated that the responses of immune system in tumor-bearing rats were more sensitive than that in nontumor-besring rats, charaterized by change of both humoral and cellular immune responses.