N－羟甲基－2－噻唑啉（硫）酮的合成

Synthesis of N-Hydroxymethyl-2-Thiazolidinone and N-Hydroxymethyl-2-Thiazolidinethione

本文的研究工作是我们在合成五元杂环化合物的系列研究工作中的一部分。主要介绍２－噻唑啉（硫）酮的氮羟甲基化反应；合成了二个新化合物Ｎ－羟甲基－２－噻唑啉酮和Ｎ－羟甲基－２－噻唑硫酮。产物元素分析，ＩＲ数据，ＨＮＭＲ数据和ＭＳ数据与目标分子结构相符。

As part of the study on the synthesis of heterocyclic compounds, this paper reports reactions of N-hydroxymetylation of 2-thiazolidinone and 2-thiazolidinethione. Two novel compounds, N-hydroxymethyl-2-thiazolidinone and N-hydroxymethyl-2-thiazolidinethione, are synthesized. The IR datum, HNMR datum, MS datum and elemental analysis of the products are in agreement with the molecular structure of the two compounds. The reaction mechanism is also discussed.