摘要
目的 探讨18F fluorouracil(FU)作为肿瘤阳性显像剂的可能性。方法 标记与合成了18F FU ,研究其在正常与荷瘤裸鼠中的生物分布 ,进行正常与荷瘤兔的PET显像。结果 HPLC及其他质控分析结果均证实18F FU动物实验与临床应用的可行性 ,生物分布及显像研究表明它在肿瘤组织中有较多的摄取。结论 18F FU是一种有潜力的肿瘤阳性显像剂。
Objective To synthesize and label a tumor positive imaging agent 18F-fluorouracil (FU) and the animal study on the product was also undertaken. Methods 18F-FU was synthesized and labeled. Its biodistribution analysis was done on normal and tumor bearing nude mice. PET imaging was performed on normal and tumor bearing rabbits. Results HPLC analysis and other quality control test results guaranteed the possibility of animal study and clinical usage of 18F-FU. Biodistribution analysis and PET imaging also demonstrated a high accumulation of the tracer in tumor tissue. Conclusion 18F-FU is a kind of potential tumor positive imaging agents which can be used to assess the effects of chemotherapy.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2001年第2期121-122,I002,共3页
Chinese Journal of Nuclear Medicine
基金
Sasagawa医学奖学金资助