石菖蒲对行为绝望动物抑郁模型的抗抑郁作用

Antidepressant Effect of Water Decoction of Rhizoma Acori Tatarinowii in the Behavioural Despair Animal Models of Depression

目的:对石菖蒲水煎剂的抗抑郁作用进行筛选研究。方法:用小鼠尾悬挂试验和大鼠强迫游泳试验抑郁模型对石菖蒲水煎剂的抗抑郁作用进行研究。结果:在小鼠尾悬挂试验和大鼠强迫游泳试验中,石菖蒲水煎剂与氟西汀一样可以使小鼠尾悬挂的失望时间和大鼠强迫游泳的不动时间显著缩短,并呈一定的剂量依赖性,但其药理作用比氟西汀弱。石菖蒲的各剂量组与生理盐水对照组比较,统计学上有非常显著性差异。结论:石菖蒲水煎剂在行为绝望动物抑郁模型上有明显抗抑郁作用。

Object:To assess the antidepressant effect of the water decoction of Rhizoma acori tatarinowii. Methods: By using the rat forced swimming test and mouse tail suispension test models of depression, the antidepressant effect of Rhizoma acori tatarinowii was observed. Results: The water decoction of Rhizoma acori tatarinowii and Fluoxetine significantly shortened motionless time of rat forced swimming and despair time of mouse tail suspension in the two behavioural despair animal models of depression. Antidepressant effect of water decoction of Rhizoma a-cori tatarinowii showed dose-dependence in the certain degree.The effect of water decoction of Rhizoma acori tatarinowii was weaker than that of Fluoxetine.There was a significant difference between every dose group of Rhizoma acori tatarinowii and saline control group. Conclusion: The water decoction of Rhizoma acori tatarinowii possessed obviously antidepressant effect in the behavioural despair animal models of depression.