p16和Rb蛋白在胃癌中的表达及其意义

Expression and Significance of p16 and Rb Protein in Gastric Carcinomas

目的 探讨p16和Rb蛋白与胃癌发生、发展、预后及化疗疗效的关系。方法 采用免疫组化S P法同步检测 5 3例胃癌组织中 p16和Rb蛋白表达。 结果 胃癌组织中 p16和Rb蛋白表达阳性率分别为 6 2 .3 %和 6 0 .4% ,p16阳性和Rb阴性表达者生存率高于 p16阴性和Rb阳性表达者。p16阴性和Rb阳性者术后辅助化疗复发转移率高于 p16阳性和Rb阴性者。 结论 p16和Rb蛋白表达 ,可作为辅助临床判断胃癌的生物学行为。

Objective To detect the expression of p16 and Rb protein in gastric cancer tissues and analyze its relationship to carcinogenesis,development,prognosis.Methods The expressions of p16 and Rb protein were detected in 53 gastric cancerous tissues by S P immunohistochemical method.Results The p16 and Rb positive rates were 62.3% and 60.4% in 53 gastric carcionsa.The 5 year survial rate of p16 positive and Rb negative patients was higher than that of p16 negative and Rb positive ones,p16 negative and Rb positive patients who received adjuvant chemotherapy had a higher metastasis rate than that of p16 positive and Rb negative patients.Conclusion The expressions of p16 and Rb protein may be an useful tumor marker for gastric cancer and can be used to evaluate the tumor biological behavior,sensitivity to the treatment and prognosis.