神经内分泌细胞与乳腺癌患者预后因素的关系

Neuroendocrine Cells and Prognosis in Mammary Carcinoma

目的 探讨乳腺癌中神经内分泌 (NE)细胞的存在及其与临床预后有关指标的关系。方法 收集乳腺癌根治术组织标本 5 3例 ,采用免疫组织化学法标记 1组NE分化的指标 :NSE、Syn、CgA以检测NE细胞的存在 ,同时行电镜检查证实。 结果 5 3例乳腺癌中 ,NSE、Syn、CgA 3种标志物均阳性 14例 ,占 2 6 .4% ,电镜检查找到肿瘤细胞中存在神经内分泌颗粒。NE阳性者淋巴结转移率高于NE阴性者 ,其 pS2蛋白和nm 2 3 H 1表达均低于NE阴性者。 结论 根据WHO分类的病理类型乳腺癌中 ,部分可存在神经内分泌细胞 ,它们属乳腺癌异质性的表现 ,具有与一般病理类型乳腺癌不完全一致的生物学行为 。

Objective To explore the relationship between the presence of neuroendocrine(NE) cells in breast cancer and some clinical pathologic factors relating to prognosis.Methods 53 cases of breast cancer received radical operation in past two years were collected,a series of neuroendocrine index such as NSE、Syn、CgA which acted as detecting the neuroendocrine cells in tumors and organs were detected by immunohistochemical techniques.Subsequently,electron microscopic examination was done to verify it.Results 14 of 53 cases were positive for NSE,Syn,CgA immunohistochemical reaction,which occupied 26.4% in total,electron dense granules in their cytoplasm were seen by election microscopy.In the group of NE positive expression,lymph node metastasis rate was higher,the expressions of pS2 protein and nm23 H1 were lower compared with those in NE negative group.Conclusion According to the classification of breast carcinoma(WHO),NE cells are present in part of them,which belong to the heterogenicity of carcinoma originating from mammary gland.They are somehow different in biological behavior from ordinary pathological subdivision so adopting suitable methods for postoperative treatment should be paid more attention.