急性心肌梗死早期及治疗后的血淋巴细胞β受体变化

The changes of β-adrenoceptors in lymphocytes after acute myocardial infarction of early and treated stage

目的 研究急性心肌梗死 (AMI)时和普萘洛尔治疗后的血淋巴细胞β受体变化以及老年人的心肌β受体水平。方法 以放射性配基结合分析法测定梗死对照组、普萘洛尔组、老年对照组及正常对照组外周血淋巴细胞β受体密度 (bmax)和平衡解离常数 (kd)值 ,并对 AMI患者进行临床观察。结果 梗死对照组 bmax、kd显著高于正常对照组 (P<0 .0 5) ,普萘洛尔组 bmax、kd用药前后比较差异显著 (P<0 .0 5)。临床观察证实普萘洛尔组心绞痛发生次数和利多卡因的用量明显低于梗死对照组。结论 β受体功能状态与 AMI病情密切相关 ,AMI早期应用β受体阻滞剂有助于改善心肌缺血缺氧 ,缩小梗死面积 。

? Objective To study the changes of β adrenoceptors in lymphocytes after acute myocardial infarction(AMI) and propranolol treatment.Methods By the method combining radioactive match radical,examining beta adrenoceptors maxdensity(bmax) and balance dividing constant(kd) in lymphocytes,doing clinic investigation of the patients in AMI.Results Bmax and kd in AMI group were higher than normal control group,with obviously different(( P <0 05).Bmax and kd in propranolol group were obvious difference after treated with propranolol( P <0 05).Conclusions The condition of beta adrenoceptors has a direct bearing on AMI.It is very important to treat with beta blockers,in orderto improve ischemic myocardium, reduce the AMI area,and decrease the arrhythmia. 〔