氯沙坦对老年高血压患者红细胞聚集性的影响

The effect of Losartan on the erythrocyte aggregation of old hypertensive patients

目的 探讨氯沙坦对老年高血压患者红细胞聚集性的影响。方法 43例老年高血压患者服用氯沙坦 50～ 1 0 0 mg治疗 1 2～ 1 7个月后观察治疗前后血液流变学指标的变化。结果 高血压患者全血低切粘度 (1 0 s- 1 )、血浆粘度及红细胞聚集指数显著增高 (P<0 .0 5) ,服用氯沙坦后高血压患者血压下降的同时全血低切粘度、血浆粘度及红细胞聚集指数显著降低 (P<0 .0 0 1 )。结论 氯沙坦可使老年高血压患者红细胞聚集性显著降低 ,血粘度下降 ,血浆粘度下降。从而降低了体内血栓形成的机会 。

? Objective To estimate the effect of losartan on the erythrocyte aggregation of elderly hypertensive patients.Methods 43 cases were chosen and then 50～100 mg losartan were administrated for 12～17 monthes,before and after the usage of Losartan,the hemorheoligic indexes were examined.Results The indexes of whole blood hemorhology and erythrocyte aggregation are increased in this group of cases.And then reduced greatly by means of Losartan administration.Conclusions Losartan could significantly lower whole hemorheology and erythrocyte aggregation.It seems to reduce the risk of thrombosis. 〔