系统性红斑狼疮患者尿α_1-微球蛋白与尿微量蛋白测定及意义

THE SIGNIFICANCE OF URINARY α_1-mG ALBUMIN WITH SYSTEMIC LUPUS ERYTHEMATOSUS

目的 了解α1-微球蛋白 (α1-mG)与尿微量白蛋白 (u -Alb)对系统性红斑狼疮 (SLE)患者早期肾损害的诊断价值。方法 通过放射免疫方法对 31例SLE患者 (尿常规正常组 10例 ,尿常规异常组 2 1例 )及 19例健康对照组的α1-mG、β2 -微球蛋白 (β2 -mG)、u -Alb进行检测。结果 SLE病人尿α1-mG、β2 -mG、u -Alb明显高于正常对照组 (P <0 .0 1)。无论尿常规正常与否 ,其尿α1-mG、β2 -mG、u -Alb均明显高于健康对照组 (P <0 .0 1)。结论 尿α1-mG及u

Objective\ To discover the diagnose value of the urinary α 1-microglobulin (α 1-mG)\,albumin to the early lupus nephritis.Methods\ In 31 patients with systemic lupus erythematosus (SLE),the urinary α 1-mG\,β 2-microglobulin (β 2-mG) and albumin were measured and compared with normal group.Results\ The results showed that the levels of α 1-mG\,β 2-mG and albumin were markedly increased in the SLE group.Either urinary RT is normal or not,the urinary α 1-mG\,β 2-mG and albumin is markedly increased compared with normal group.Conclusion\ The urimary α 1-mG、albumin content might be used as a sensitive marker for early lupus nerphritis.