白塞氏病患者血清t-PA、PAI的变化及临床意义

Evaluation of serum t-PA and PAI levels in patients with Bechet′s disease

目的 检测白塞氏病 (BD)患者血清组织纤溶酶原激活剂 (t PA)、组织纤溶酶原激活剂抑制物 (PAI)水平的变化 ,并探讨与疾病的相关性。方法 应用发色底物法测定 2 4例BD患者血清t PA、PAI水平 ,并分疾病活动组、稳定组与正常对照组相比较。结果 BD组t PA水平较正常对照组显著降低 (P <0 0 5 ) ,而PAI水平则显著升高 (P <0 0 5 ) ,BD活动组t PA水平较稳定组非常显著降低 (P <0 0 1) ,PAI水平则非常显著升高 (P <0 0 1)。结论 纤溶凝血系统可能在BD发病机制中起一定作用 ,并与疾病活动有密切相关性。

Objective To examine serum tissue plasminogen activator(t PA) and plasminogen activator inhibitor(PAI) levels in patients with Behcets disease(BD),and to discuss their relationship with disease.Methods 24 patients with BD were classified as active and inactive,and 20 healthy individuals as normal controls(NC) were included in this study.The t PA and PAI were determined using the method of chromogenic substances.Results In the active patient group t PA levels were significantly lower( P <0 01) than the inactive and control groups with higher levels of PAI ( P <0 05 and P <0 01 respectively).Conclusion Fibrinolytic system may play some role in the pathogenesis of BD,and seems to have close correlation with activity of the disease.