癌胚抗原生物半衰期监测恶性肿瘤的评价

Significance of serum carcinoembryonic antigen biological half-life for patients with malignant tumors

目的 观察恶性肿瘤患者血清癌胚抗原 (CEA)半衰期 (T1 /2 )在术后监测中的意义 .方法 应用单克隆双抗体夹心酶免疫一步法分别检测治疗前、后血清 CEA.结果 治疗后血清 CEA预测恶性肿瘤复发或转移的敏感性 ,特异性和总符合率 (准确度 )分别为 5 6 % ,82 %和 77% ,而 CEA半衰期T1 /2 >15 d时分别高达 89% ,94%和 93% .结论 血清 CEAT1 /2 检测优于 CEA测定 ,术后残余癌细胞越多 CEA T1 /2 越长 ,故 CEA T1 /2

AIM To study the meaning of serum carcinoembryonic antigen (CEA) biological half life ( T 1/2 ) for the patients with malignant tumors. METHODS CEA contens in serum were determined by one step double sandwich ELISA. RESULTS Sensitivity, specificity and accuracy of predicting malignant tumors recurrent and metastasis after treatment serum CEA levels were 56%, 82%, 77% respectively. Whereas CEA T 1/2 >15 d, the sensitivity, specificity and accuracy were 89%, 94%, 93% respectively. CONCLUSION Analysis of CEA T 1/2 in serum is better than serum CEA total levels measurement. The more residual cancer cells ex ist the longer CEA T 1/2 is. Therefore CEA T 1/2 is a sensitive target to predict the early stage tumor recurrence and metastasis.