乙酸局部注射治疗裸鼠移植性肝癌

Treatment of transplanted hepatocellular carcinoma in nude mice with local acetic acid injection

目的 观察局部注射乙酸对裸鼠移植性肝癌的治疗作用 ,为临床应用此方法治疗肝癌提供实验依据 .方法 建立裸鼠移植性肝癌模型 ,观察治疗后肿瘤体积、光镜及电镜变化 .结果 在第 4次注射乙酸前 ,裸鼠移植瘤消失 ,疗效优于乙醇注射组 (P<0 .0 1) ,且无明显毒副作用 .结论 乙酸可用于肝癌的局部注射治疗 。

AIM To observe the effects of local acetic acid injection on hepatocellular carcinoma. METHODS By establishing a model of transplanted tumor in nude mice, the changes of size and histology of tumor were observed after injecting acetic acid, ethanol and saline. RESULTS Transplanted hepatocellular carcinoma disappeared before the fourth injecting acetic acid. The treatment effect of acetic acid injection on hepatocellular carcinoma was superior to ethanol injection. There were no significant toxic and side effects after acetic acid injection. CONCLUSION Acetic acid can be used for local injection therapy on hepatocellular carcinoma.